Wednesday, 24 July at Courtyard Newark-UD, Newark, DE  19716

Sponsored by the Biomolecular Interaction Technologies Center


Alex MacKerell, SilcsBio, LLC, Rational Excipient Design for Protein-based Drugs using the Site Identification by Ligand Competitive Saturation (SILCS) Technology

Jason Coleman, Precision NanoSystems, NanoAssemblr Technology for Nucleic Acid Therapeutics

Thomas Weber, Dynamic Biosensors GmbH, SwitchSENSE®: Biophysical Analysis of Molecular Interactions with Electro- Switchable Biosurfaces

Belinda Pastrana Rios, Protein Dynamic Solutions, ProteinMentor: a Breakthrough Platform Technology for Developability and Comparability Assessment of Therapeutic Proteins in Solution

Eugene Ma, RedShift BioAnalytics Inc., Applications of Microfluidic Modulation Spectroscopy for Automated Secondary Structural Analysis of Protein Therapeutics

Julie DeSa Lorenz, On-Line Instrument Systems, Inc., Absorbance Spectroscopy in Alhydrogel & Other Drug Delivery Media

Laura Philips, Spheryx, Inc., Detecting, Counting and Characterizing Sub-Visible Protein Aggregates with Holographic Video Microscopy

Gabriel Popescu, Phi Optics, Particle Characterization in the 10nm-1mm Range Using Phi Optics Technology


2018 BITC Summer Symposium

Wednesday, 25 July at Embassy Suites Hotel, Newark, DE  19713

Sponsored by the Biomolecular Interaction Technologies Center

View Programme


Mark Fisher, University of Kansas, Using Biolayer Interferometry Chaperonin Biosensors to Detect Transiently Populated Preaggregate States under Non-Stressed Temperature Conditions

Michael Brenowitz, Einstein Medical School, Is Protein Oxidative Footprinting Ready for Prime Time?

Bruce Yu, University of Maryland, Water Proton NMR: Noninvasive Analytic for Biopharmaceutical Manufacturing and Quality Control

Jack Correia, University of Mississippi, The Use of FDS AUC to Perform High-Concentration Biophysics

Tom Laue, University of New Hampshire, IgG Allostery?

Mark Chiu, Janssen Pharmaceuticals, Kinetic Mechanism of Controlled Fab-Arm Exchange for the Formation of Bispecific Immunoglobulin G1 Antibodies

James Swan, MIT, From hindered to promoted settling in dispersions of attractive colloids: Simulation, modeling, and application to macromolecular characterization

Pete Tessier, University of Michigan, Physicochemical Determinants of Drug-like Monoclonal Antibodies

2017 BITC Summer Symposium

Thursday, 13 July at Embassy Suites Hotel, Newark, DE 19713

Sponsored by the Biomolecular Interaction Technologies Center

View Programme


Adam Zwolak, Janssen Pharmaceuticals, “Characterizing the Oligomerization of Biologics in Serum Using Fluorescence Size–Exclusion Chromatography”

Eric Furst, University of Delaware, “High-throughput Viscosity Measurements of mAbs, mAb Mixtures and Bispecifics”

Jason Cheung, Merck & Co., “The Use of Biophysical Characterization During Product Development”

Jeff Hudgens, NIST, “Hydrogen-Deuterium Mass Spectrometry for Characterizing IgG1 Dynamics and IgG1-FdgR Binding”

Frank Delaglio, University of Maryland/NIST IBBR, “Fingerprinting Higher–Order Structure of mAb Biologics with NMR”

Marco Blanco, NIST, “Inter-domain Interactions and their Role on the Colloidal Stability of Concentrated Antibody Solutions”

Cavan Kalonia, NIST, “Adsorption of the NIST IgG1 Monoclonal Antibody to Solid Interfaces Can Cause Subvisible Particles to be Released into Solution During Flow”


2016 SUMMER BITC Symposium

Thursday, 12 July at Embassy Suites Hotel, Newark, DE 19713

Sponsored by the Biomolecular Interaction Technologies Center

View Programme


Tatyana Polenova, University of Delaware, “Magic Angle Spinning NMR for Atomic-Level Structure and Dynamics Analysis of Biological Assemblies”

Robert Fairman, Haverford College, “Daring to BOLT Forward to the Study of Human Neurodegeneration in Transgenic Animals Using the Analytical Ultracentrifuge”

Abraham Lenhoff, University of Delaware, “Molecular Origins of High Viscosity in mAb Solutions”

Mahlet Woldeyes, University of Delaware, “Comparison of Protein-Protein Interactions Across Light Scattering Platforms, and as a Predictor of Elevated Viscosity”

Robert Hart, Optofluidics, “Hexpoint: Rapid, Low Volume Biopharmaceutical Particle Analysis with Fluorescent Typing”

Gavin Ferlic, LiteSprite, “Laser Transmission Spectroscopy: A New Window to the Nano World”


2014 SUMMER BITC Symposium

Monday, 4 August at Embassy Suites Hotel, Newark, DE 19713


John Tsavalas, University of New Hampshire, “Multimer protein cluster structure at high concentration: dynamic modeling of stability and viscosity”

Eric Furst, University of Delaware, “Protein solution microrheology”

Jeremy Schmit, Kansas State University, “Simple models of antibody solution viscosity”

Michael Brenowitz, Albert Einstein College of Medicine – “Mapping molecular interfaces”

Ed Lyman, University of Delaware, “Understanding how lipids modulate G-protein coupled receptors with theory and molecular simulation”

Neil Lewis, Malvern Instruments, “Combining raman spectroscopy and dynamic light scattering for developing unique insights into protein structure and stability”

Abraham Lenhoff, University of Delaware, “Characterization by scattering methods of protein phases in downstream processing and formulations”

Steven R. Aubuchon & Paulius Vaitiekunas, TA Instruments, “Calorimetric studies of biomolecular interactions”

John Champagne, Wyatt Technologies,  “From mobility to stability: light scattering solutions for formulating stable biotherapeutics”

Keynote Speaker:  Allen Minton, National Institutes of Health, “Detection and quantitative characterization of macromolecular heteroassociation by composition gradient – sedimentation equilibrium”



Monday, 22  July



Dana Aswad, University of Callifornia, Irvine, “Isoaspartate Formation:  Effects on Protein Structure and Function”

Dr. Roy Jefferis, Univeristy of Birmingham UK, “Structural and functional propfiles of protein and glycoform engineered human IgG”

Brian Baker, University of Notre Dame, “Molecular Flexibilty in T Cell Receptor of Antigen”

Tom Patapoff, Genentech, Inc., S. San Francisco, CA, “Elucidation of Antibody Motion Using All Atom Molecular Dynamics”

Floyd Romersberg, The Scripps Research Institute, CA, “The Evolution of Immunological Molecular Recognition”

Steven J. Shire, Genentech, Inc., S. San Francisco, CA, “Impact of Protein Conformation and Flexibility on Asp Isomerization Rates”

Joerg Zimmerman, The Scripps Research Institute, CA, “The Jiggling and Wiggling – Quantification of Antibody Flexibility”


2012 summer BITC SYMPOSIUM

Monday, 16 July at University of New Hampshire, Durham



Anuj Chaudhri, University of Chicago: “Self-Association of Therapeutic Monoclonal Antibodies:  A Coarse-Grained Perspective on the Role of  Electrostatics and More”

Kenneth Christensen, Clemson University: “Capillary-channeled polymer fibers and nanofiber yarns as a platform for detection of biomolecular interactions”

Thomas Laue, University of New Hampshire:  “Methods for Charge Measurement”

Chris Roberts, University of Delaware:  “Protein interactions from low to high concentrations:  new approaches via scattering and protein engineering”

Peter Tessier, Rensselaer Polytech:  “Engineering aggregation-resistant antibodies”

John Tsavalas, University of New Hampshire:  “Dynamic Protein-Protein Interaction Modeling in Highly Concentrated Solutions:  Rheology and Stability”

Sandeep Yadav, Genentech:  “The Significance of Molecular Charge in Various Aspects of Product Development:  Can we Afford to Overlook it”