Prior Workshops:
2017 bitc spring WORKSHOP
Tuesday-Wednesday, 21-22 March at Embassy Suites Hotel, Newark, DE
PREDICTING THE PROPERTIES OF PHARMACEUTICAL PROTEIN SOLUTIONS: FROM MOLECULAR TO PHENOMENOLOGICAL APPROACHES
Sponsored by the Biomolecular Interaction Technologies Center
INSTRUCTORS:
Jeremy Schmit, Kansas State University, “Can Protein Viscosity be Predicted from Two-Body Interactions?”
Sandeep Kumar, Pfizer, “Notes in Biopharmaceutical Informatics: Aggregation of Therapeutic Antibodies”
Abraham Lenhoff, University of Delaware, “Occam’s Razor in Modeling Protein-Protein Interactions”
Tom Laue, University of New Hampshire, “Applications of AU-FDS to Interactions in High Concentration Systems”
Jai Pathak, National Institutes of Health, “Rheology of Antibody/Protein Solutions: Advances & Next Frontiers”
Lydia Beasley & Tom Patapoff, Genentech, “Molecular Dynamics and Machine Learning to Predict Chemical Stability”
Angel Garcia, Los Alamos National Laboratory, “Molecular Simulations of Cosolvent Effects on Protein Stability”
M. Scott Shell, UC Santa Barbara, “Systematic Methods to Generate Coarse-Grained Models of Peptides and
Aqueous Solvation”
Robin Curtis, University of Manchester, “The Impact of Arginine-Lysine Mutations on Aggregation Properties of Proteins”
2010 bioassays: the good, the bad and the ugly!
SPEAKERS:
Mark Chiu, Abbott Laboratories
Thomas Glass, Sapidyne Instruments, Inc.
Stephen Krause, MedImmune
Jean Lee, Amgen Inc.
Eric D. Roush, GE Healthcare
Bruce Thompson, Pfizer
Mohammed Yousef, Bio-Rad
2009 aaps workshop on methods for detecting and characterizing sub-visible particulates
SPEAKERS:
Steven J. Shire, Ph.D., Genentech, Inc.
Barthelemy Demeule, Ph.D.,University of Geneva and University of Lausanne
Matt Rhyner, Ph.D. Beckman Coulter Inc.
John Champagne, Wyatt Technology Inc
Sampath Krishnan, Amgen Inc.
Thomas M. Scherer, Ph.D., University of Massachusetts
Deepak K. Sharma, Ph.D., Brightwell Technologies Inc.
2008 REFORM SCHOOL FOR ILL-BEHAVED PROTEINS
SPEAKERS:
Allen Minton, National Institutes of Health, “New light scattering method for detection and characterization of protein association in highly concentration solution”
Jun Liu, Genentech, Inc., “Misbehaving Proteins – A Perspective from Biopharmaceutical Industry”
C.Russ Middaugh, University of Kansas, “The Polyanion World and Ill-Behaved Proteins”
Christopher J. Roberts, University of Delaware, “What controls non-native aggregation of foldable Proteins? Competing views from polymer physics, colloid science, and protein chemistry”
Yatin Gokarn, Amgen, Inc., “Good Proteins, Bad Environment: Role of Effective Charge in Governing Stability, Solubility & Rheology”
Thomas Malia, Centocor, Inc., “Refolding of soluble and membrane proteins: methods and structural characterization”
2007 CHARACTERIZING THE PHYSICAL PROPERTIES OF PURIFIED ANTIBODIES
SPEAKERS:
Sandra Smith-Gill, National Cancer Institute, NIH, “Thermodynamics and time-dependent stability of antibody-antigen complexes”
Steve Shire, Genetech, Inc., “Monoclonal antibody viscosity and self-association: analytics and interpretation of results”
Nick Pace, Texas A & M University, “Protein stability and solubility: contribution of net charge and individual amino acid side chains”
Wayne Bolen, University of Texas Medical Branch, “Relating protein-osmolyte interactions to Protein solubility and stability”
Eric Sundberg, Boston Biomedical Research Institute, “Energetic cooperativity in protein-protein interactions”
2006 WORKSHOP: MEMBRANE PROTEIN INTERACTIONS
2004 WORKSHOP: INNOVATIONS IN ANALYTICAL ULTRACENTRIFUGATION AND SURFACE PLASMON RESONANCE: ADVANCED INSTRUMENTS AND ANALYSIS SOFTWARE
SPEAKERS:
Walter Stafford, Boston Biomedical Research Institute
David Myszka, University of Utah
Thomas Laue, Center to Advance Molecualr Itneraction Science
Simon Cocklin, Drexel University
Kenneth Miller and Brian Lang, Biacore
2003 WORKSHOP: FLUORESCENCE SPECTROSCOPY OF LIGAN BINDING
SPEAKERS:
Joe Beechem, Molecular Probes: HTS assays
Zygmunt Gryczynski, Center for fluorescence Spectrosocpy: General principles, polarization, new developments
Nancy Thompson, U. North Carolina: TIRF
James Foley, Rowland Institute, Harvard: Fluorescent dyes
Curve Fitting and Data Analysis, July 2002
Norma Greenfied, UNJMD, circular dichroism
Tom Laue, CAMIS, sedimentation equilibrium
Ernst Linder, UNH, generalized curve fitting
David Myszka, U. Utah, surface plasmon resonance
John Philo, Alliance Protein, sedimentation velocity
2002 WORKSHOP: CURVE FITTING AND DATA ANALYSIS
Prior ROUNDTABLES:
2011 ROUndtable: methods used to determine higher order structural changes in protein biotherapeutics
17 March 2011; South San Francisco CA
Speakers:
Steven Berkowitz, BiogenIdec “The Use of Hydrogen/Deuterium Exchange-Mass Spectrometry (H/DX-MS) in the Biopharmaceutical Industry”
Stephen Harding, University of Nottingham “Hydrodynamic conformation and aggregation of antibodies and larger glycoconjugates”
Yen-Hue Lin, Human Genome Sciences “Qualification of Biophysical Methods and use with Analytical Comparability Assessments”
David Volkin, University of Kansas “Protein particulates/aggregates and empirical phase diagrams to characterize 2/3 structure of proteins”
2010 ROUNDTABLE: MICROVISCOSITY
2009 ROUNDTABLE: HIGH THROUGHPUT CALORIMETRY
2008 ROUNDTABLE: DISCUSSION ON COMPARABILITY
2007 ROUNDTABLE: WHAT’S NEW IN SPR?
2006 ROUNDTABLE: INNOVATIONS IN SURFACE TECHNOLOGIES
2005 ROUNDTABLE: FTIR AND RAMAN SPECTROSCOPY APPLICATIONS IN DRUG DISCOVERY
2004 ROUNDTABLE: QUANTUM DOT TECHNOLOGIES IN PHARMACEUTICAL RESEARCH
2003 ROUNDTABLE: ATOMIC FORCE MICROSCOPY IN PHARMACEUTICAL APPLICATIONS