The Biomolecular Interaction Technologies Center (BITC) at the University of Delaware is presently soliciting research proposals for funding.

BITC is an Industry/University Cooperative Research Center established to carry out research in coordination with pharmaceutical or biotechnology company partners. Proposals are funded via industry contributions to the Center; hence, the research must be of interest and importance to these industries. Proposals will be accepted until June 15, 2017 with review and decisions being made approximately in August 2017. For additional information, explore the proposal guidelines.

Research proposals should deal with methods preferably based on first principles that can be used to quantitate the binding interaction between molecular species. Proposals can be for the development of new methods or refinement of existing methodology to make it a practical method. The research should be aimed toward making the technique or method one that could be used on a routine basis for either molecular screening or as an analytical technique.

Submit a proposal via e-mail as an RTF or Word document, or PDF. Include estimated cost, duration of project and credentials.

E-mail to:

Dr. Christopher J. Roberts
BITC Director
223 Colburn Laboratory
150 Academy Street
University of Delaware
Newark, DE 19716
Tel: 302-831-0838

Publications from BITC-funded Research

Klitgaard, Soren; Shtoyko, Tanya; Calander, Nils; Gryczynski, Ignacy; Matveeva, Evgenia; Borejdo, Julian; Neves-Petersen, Maria; Petersen, Steffen; Gryczynski, Zygmunt. Long wavelength depolarized light scattering from silver nanoparticles. Chemical Physics Letters 443 (2007), 1-5.

Matveeva, Evgenia; Gryczynski, Ignacy; Barnett, Anne; Calander, Nils; Gryczynski, Zygmunt. Red blood cells do not attenuate the SPCE fluorescence in surface assays. Anal Bioannal Chem (2007) 388:1127-1135.

Matveeva, Evgenia; Gryczynski, Ignacy; Barnett, Anne; Leonenko, Zoya; Lakowicz, Joseph; Gryczynski, Zygmunt. Metal particle-enhanced fluorescent immunoassays on metal mirrors. Analytical Biochemistry 363 (2007) 239-245.

Gryczynski, Zygmunt; Matveeva, Evgenia; Calander, Nils; Zhang, Jian; Lakowicz, Joseph; Gryczynski, Ignacy. Surface Plasmon Coupled Emission. Surface Plasmon Nanophotonics (2007) 247-265.

Matveeva, Evgenia; Gryczynski, Ignacy; Barnett, Anne; Calander, Nils; Gryczynski, Zygmunt. Absorbing/Scattering Background Elimination in Directional SPCE. Biosensors and Bioelectronics (2006).

Laue, Thomas M.; Austin, Joseph B.; Rau, David A. A light intensity measurement system for the analytical ultracentrifuge. Progress in Colloid and Polymer Science (2006), 131 1-8.

Smith, Derek S.; Kostov, Yordan; Rao, Govind; Gryczynski, Ignacy; Malicka, Joanna; Gryczynski, Zygmunt, and Lakowicz,Joseph R. First observation of surface plasmon-coupled emission due to LED excitation. Journal of Fluorescence (© 2005). Online 3 Dec. 2005. DOI: 10.1007/s10895-005-0021-4.

MacGregor, Ian K.; Anderson, Arthur L.; Laue, Thomas M.. Fluorescence detection for the XLI analytical ultracentrifuge. Biophysical Chemistry (2004), 108(1-3), 165-185.

Laue, Thomas. Analytical ultracentrifugation: a powerful ‘new’ technology in drug discovery. Drug Discovery Today: Technologies. (2004), 1 (3). DOI:10.1016/j.ddtec.2004.11.012

Gryczynski, Ignacy; Malicka, Joanna; Lukomska, Joanna; Gryczynski, Zygmunt, and Lakowicz, Joseph R. Surface Plasmon-coupled polarized emission of N-Acetyl-L-Tryptophanamide. Photochemistry and Photobiology (2004), 80: 482-485

Stenlund, Peter; Babcock, Gregory J.; Sodroski, Joseph; and Myszka, David G. Capture and reconstitution of G protein-coupled receptors on a biosensor surface. Analytical Biochemistry (2003) 316: 243–250. DOI:10.1016/S0003-2697(03)00046-0