The Biomolecular Interaction Technologies Center issues this annual request for research grants. The mandate of BITC is to better characterize, quantify, and/or predict interactions between biomolecules such as therapeutic proteins. This includes: (i) developing new instruments or methods or related technologies; (ii) or refining / adapting existing equipment, techniques, or approaches.

Specific to the project call for 2018, the following areas will be prioritized within the broader scope of BITC:

1. Novel techniques/instruments evaluation including automation of historically low-throughput techniques
2. Linking biophysical attributes with avidity and cooperative binding, including bioassay as well as in vitro and in vivo models for protein stability in tissues and serum
3. Software development for prediction of protein-protein interactions, ultimately including predictions of aggregation rates/long-term stability, viscosity, and filtration performance

In addition, projects in which one or more co-principal investigators are included from BITC member companie(s) will be given priority.

Proposals must be received electronically by 5:00 pm EDT on July 16, 2018.

Prior to submitting a proposal, contact the BITC Director (Chris Roberts, email: cjr@udel.edu) for a pre-proposal review electronically or by phone appointment. Proposals submitted without a pre-proposal review may be returned without panel review if they are not aligned with BITC goals.

Formatting:

• document length should be no longer than 5 pages, including figures and tables, but not including references or appendix for budget only (see below).
• 1 inch margins
• single space, minimum 11 point Arial or Times New Roman font

Proposal Contents:

1. Title
2. Name of PI and Institution
3. Start Date: new (non-continuing) BITC projects begin with a 1 January start date of the year after the proposal is reviewed and approved.
4. Project Summary:
a. A concise statement of the proposed work, motivation, and expected outcome(s)
5. Project Description:
a. A discussion stating the background and proposed approach, novelty of the approach, and a timeline of the methods development and deliverables.
6. List of key personnel, if applicable
7. References (not included in page limit)
8. Appendix for annual budget (not included in page limit): a budget template is available upon request. Maximum annual budget (direct cost) is $45,000. No indirect costs are allowable.  Budget must incorporate the following:
a. Salaries and benefits, student stipend and/or tuition, supplies, travel (travel expenses are limited to $2,000 per project year unless essential for completion of the work)
b. no F&A is allowed
c. Initial project duration is 1 year, renewable for up to one additional year upon successful completion of year-one deliverables and subject to approval of the BITC board

Must include a 1-page budget justification (not included in page limit).

Submit via email to Kristi Halberg: khalberg@udel.edu

Dr. Christopher J. Roberts
BITC Director
223 Colburn Laboratory
150 Academy Street
University of Delaware
Newark, DE 19716
Tel: 302-831-0838